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Issue 66, 2016
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Cytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates – synthesis, aqueous stability and X-ray structure analysis

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Abstract

Herein we report the synthesis and structural characterization of a series of novel Zr(IV)salan complexes. The initial metalation product [(L1)2Zr] is highly water sensitive while ligand exchanged [L1Zr(dipic)] hydrolyses slowly with a bis-hydroxo Zr(IV) species identified by MS as an intermediate. [L1Zr(dipic)] is cytotoxic in the range of cisplatin against two human carcinoma cell lines.

Graphical abstract: Cytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates – synthesis, aqueous stability and X-ray structure analysis

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Supplementary files

Article information


Submitted
27 Jun 2016
Accepted
21 Jul 2016
First published
21 Jul 2016

This article is Open Access

Chem. Commun., 2016,52, 10151-10154
Article type
Communication

Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates – synthesis, aqueous stability and X-ray structure analysis

F. Schneider, T. Zhao and T. Huhn, Chem. Commun., 2016, 52, 10151
DOI: 10.1039/C6CC05359A

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