Rhodium(II)–fluorophore conjugates have strong rhodium-based fluorescence quenching that can be harnessed to report on a conjugate's cellular uptake and the intracellular decomposition rate. Information gleened from this study allowed the design of an improved STAT3 metalloinhibitor.
M. B. Minus, M. K. Kang, S. E. Knudsen, W. Liu, M. J. Krueger, M. L. Smith, M. S. Redell and Z. T. Ball, Chem. Commun., 2016, 52, 11685 DOI: 10.1039/C6CC05192H
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