Issue 75, 2016

Nanoparticle “switch-on” by tetrazine triggering


This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels–Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.

Graphical abstract: Nanoparticle “switch-on” by tetrazine triggering

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Article information

Article type
19 Jun 2016
19 Aug 2016
First published
19 Aug 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 11223-11226

Nanoparticle “switch-on” by tetrazine triggering

K. Neumann, S. Jain, J. Geng and M. Bradley, Chem. Commun., 2016, 52, 11223 DOI: 10.1039/C6CC05118A

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