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Issue 81, 2016
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Stabilisation of metastable polymorphs: the case of paracetamol form III

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Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Graphical abstract: Stabilisation of metastable polymorphs: the case of paracetamol form III

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Supplementary files

Article information


Submitted
15 Jun 2016
Accepted
05 Aug 2016
First published
05 Aug 2016

This article is Open Access

Chem. Commun., 2016,52, 12028-12031
Article type
Communication

Stabilisation of metastable polymorphs: the case of paracetamol form III

R. Telford, C. C. Seaton, A. Clout, A. Buanz, S. Gaisford, G. R. Williams, T. J. Prior, C. H. Okoye, T. Munshi and I. J. Scowen, Chem. Commun., 2016, 52, 12028
DOI: 10.1039/C6CC05006A

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