Tuan Trinh, Pongphak Chidchob, Hassan S. Bazzi and Hanadi F. Sleiman
Chem. Commun., 2016,52, 10914-10917
DOI:
10.1039/C6CC04970B,
Communication
We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.