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Issue 72, 2016
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DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

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Abstract

We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.

Graphical abstract: DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

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Article information


Submitted
14 Jun 2016
Accepted
07 Aug 2016
First published
09 Aug 2016

Chem. Commun., 2016,52, 10914-10917
Article type
Communication
Author version available

DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

T. Trinh, P. Chidchob, H. S. Bazzi and H. F. Sleiman, Chem. Commun., 2016, 52, 10914
DOI: 10.1039/C6CC04970B

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