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Issue 66, 2016
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Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(II) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

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Abstract

Two thermally activated ruthenium(II) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1–9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.

Graphical abstract: Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

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The article was received on 08 Jun 2016, accepted on 21 Jun 2016 and first published on 23 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC04813G
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Citation: Chem. Commun., 2016,52, 10121-10124

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    Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(II) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

    E. Wachter, A. Zamora, D. K. Heidary, J. Ruiz and E. C. Glazer, Chem. Commun., 2016, 52, 10121
    DOI: 10.1039/C6CC04813G

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