Issue 61, 2016
From the journal:

Chemical Communications

A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors†

Leonardo Degennaro,*a   Daniela Maggiulli,a   Claudia Carlucci,a   Flavio Fanelli,a   Giuseppe Romanazzib  and  Renzo Luisi*a  

* Corresponding authors

a Department of Pharmacy – Drug Sciences, University of Bari “A. Moro”, FLAME – Lab Flow Chemistry and Microreactor Technology Laboratory, Via E. Orabona 4, Bari 70125, Italy
E-mail: leonardo.degennaro@uniba.it, renzo.luisi@uniba.it

b DICATECh, Politecnico di Bari, Via E. Orabona 4, Bari 70125, Italy

Abstract

Tertiary butyl esters find large applications in synthetic organic chemistry. A straightforward method for the direct introduction of the tert-butoxycarbonyl group into a variety of organic compounds has been developed using flow microreactor systems. The resultant flow process was more efficient, versatile and sustainable compared to the batch.

Graphical abstract: A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors

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Article information

DOI
https://doi.org/10.1039/C6CC04588J
Article type
Communication
Submitted
01 Jun 2016
Accepted
29 Jun 2016
First published
30 Jun 2016

Chem. Commun., 2016,52, 9554-9557

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A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors

L. Degennaro, D. Maggiulli, C. Carlucci, F. Fanelli, G. Romanazzi and R. Luisi, Chem. Commun., 2016, 52, 9554 DOI: 10.1039/C6CC04588J

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