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Issue 68, 2016
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An in-tether sulfilimine chiral center induces helicity in short peptides

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Abstract

A precisely positioned sulfilimine chiral center in the tether of a stabilized peptide would determine the peptide's secondary structure. Peptide sulfilimines could be prepared by a facile chloramine T oxidation and the two resulting peptide diastereomers showed significant differences in their secondary structures, which were supported by circular dichroism spectroscopy and NMR.

Graphical abstract: An in-tether sulfilimine chiral center induces helicity in short peptides

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Publication details

The article was received on 29 May 2016, accepted on 26 Jul 2016 and first published on 26 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC04508A
Citation: Chem. Commun., 2016,52, 10389-10391
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    An in-tether sulfilimine chiral center induces helicity in short peptides

    H. Lin, Y. Jiang, Q. Zhang, K. Hu and Z. Li, Chem. Commun., 2016, 52, 10389
    DOI: 10.1039/C6CC04508A

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