Issue 59, 2016

Paramagnetic lanthanide chelates for multicontrast MRI

Abstract

The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.

Graphical abstract: Paramagnetic lanthanide chelates for multicontrast MRI

Supplementary files

Article information

Article type
Communication
Submitted
12 May 2016
Accepted
02 Jun 2016
First published
02 Jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 9224-9227

Paramagnetic lanthanide chelates for multicontrast MRI

N. Cakić, T. Savić, J. Stricker-Shaver, V. Truffault, C. Platas-Iglesias, C. Mirkes, R. Pohmann, K. Scheffler and G. Angelovski, Chem. Commun., 2016, 52, 9224 DOI: 10.1039/C6CC04011J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements