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Issue 59, 2016
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Paramagnetic lanthanide chelates for multicontrast MRI

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Abstract

The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.

Graphical abstract: Paramagnetic lanthanide chelates for multicontrast MRI

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Supplementary files

Article information


Submitted
12 May 2016
Accepted
02 Jun 2016
First published
02 Jun 2016

This article is Open Access

Chem. Commun., 2016,52, 9224-9227
Article type
Communication

Paramagnetic lanthanide chelates for multicontrast MRI

N. Cakić, T. Savić, J. Stricker-Shaver, V. Truffault, C. Platas-Iglesias, C. Mirkes, R. Pohmann, K. Scheffler and G. Angelovski, Chem. Commun., 2016, 52, 9224
DOI: 10.1039/C6CC04011J

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