Issue 59, 2016

Paramagnetic lanthanide chelates for multicontrast MRI


The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.

Graphical abstract: Paramagnetic lanthanide chelates for multicontrast MRI

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Article information

Article type
12 May 2016
02 Jun 2016
First published
02 Jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 9224-9227

Paramagnetic lanthanide chelates for multicontrast MRI

N. Cakić, T. Savić, J. Stricker-Shaver, V. Truffault, C. Platas-Iglesias, C. Mirkes, R. Pohmann, K. Scheffler and G. Angelovski, Chem. Commun., 2016, 52, 9224 DOI: 10.1039/C6CC04011J

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