Issue 62, 2016

Rhodium(iii)-catalyzed alkylation of primary C(sp3)–H bonds with α-diazocarbonyl compounds

Abstract

Rh(III)-catalyzed intermolecular chelation-assisted insertion of carbenes derived from α-diazocarbonyl compounds into non-acidic primary sp3 C–H bonds, for the first time, is reported under mild reaction conditions, thus affording a good complement to previous metal-carbenoid-induced primary C(sp3)–H insertion reactions. We believe that this method will open up a new avenue for primary sp3 C–H functionalization with α-diazocarbonyl compounds.

Graphical abstract: Rhodium(iii)-catalyzed alkylation of primary C(sp3)–H bonds with α-diazocarbonyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
07 May 2016
Accepted
29 Jun 2016
First published
30 Jun 2016

Chem. Commun., 2016,52, 9672-9675

Rhodium(III)-catalyzed alkylation of primary C(sp3)–H bonds with α-diazocarbonyl compounds

W. Hou, Y. Yang, Y. Wu, H. Feng, Y. Li and B. Zhou, Chem. Commun., 2016, 52, 9672 DOI: 10.1039/C6CC03846H

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