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Issue 59, 2016
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Active tumor-targeting luminescent gold clusters with efficient urinary excretion

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Abstract

We present novel active targeting luminescent gold nanoclusters (AuNCs), which are prepared through a one-pot procedure by using a pentapeptide (CRGDS) for stabilization and tumor recognition. CRGDS–AuNCs exhibit a high tumor-specific retention with an exceptionally high tumor-to-liver uptake ratio of 9.3. Their small hydrodynamic diameter and zwitterionic surface facilitate urinary excretion, which reaches 82% within 24 h after injection.

Graphical abstract: Active tumor-targeting luminescent gold clusters with efficient urinary excretion

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Supplementary files

Article information


Submitted
06 May 2016
Accepted
17 Jun 2016
First published
17 Jun 2016

This article is Open Access

Chem. Commun., 2016,52, 9232-9235
Article type
Communication

Active tumor-targeting luminescent gold clusters with efficient urinary excretion

X. Wang, H. He, Y. Wang, J. Wang, X. Sun, H. Xu, W. M. Nau, X. Zhang and F. Huang, Chem. Commun., 2016, 52, 9232
DOI: 10.1039/C6CC03814J

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