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Issue 55, 2016
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Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA

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Abstract

The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst.

Graphical abstract: Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA

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Article information


Submitted
27 Apr 2016
Accepted
10 Jun 2016
First published
10 Jun 2016

Chem. Commun., 2016,52, 8604-8607
Article type
Communication

Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA

N. Duchemin, E. Benedetti, L. Bethge, S. Vonhoff, S. Klussmann, J. Vasseur, J. Cossy, M. Smietana and S. Arseniyadis, Chem. Commun., 2016, 52, 8604
DOI: 10.1039/C6CC03540J

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