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Issue 54, 2016
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Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

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Abstract

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18F]KF/K222 in the presence of Cu(OTf)2py4. The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of 18F-fluoride.

Graphical abstract: Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

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Supplementary files

Article information


Submitted
19 Apr 2016
Accepted
23 May 2016
First published
23 May 2016

Chem. Commun., 2016,52, 8361-8364
Article type
Communication

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

S. Preshlock, S. Calderwood, S. Verhoog, M. Tredwell, M. Huiban, A. Hienzsch, S. Gruber, T. C. Wilson, N. J. Taylor, T. Cailly, M. Schedler, T. L. Collier, J. Passchier, R. Smits, J. Mollitor, A. Hoepping, M. Mueller, C. Genicot, J. Mercier and V. Gouverneur, Chem. Commun., 2016, 52, 8361
DOI: 10.1039/C6CC03295H

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