Issue 49, 2016
From the journal:

Chemical Communications

Screening of a virtual mirror-image library of natural products†

Taro Noguchi,a   Shinya Oishi,*a   Kaori Honda,b   Yasumitsu Kondoh,b   Tamio Saito,b   Hiroaki Ohno,a   Hiroyuki Osadab  and  Nobutaka Fujii*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: soishi@pharm.kyoto-u.ac.jp, nfujii@pharm.kyoto-u.ac.jp
Fax: +81 75-753-4570

b RIKEN CSRS, Wako, Saitama 351-0198, Japan

Abstract

We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using D-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.

Graphical abstract: Screening of a virtual mirror-image library of natural products

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Article information

DOI
https://doi.org/10.1039/C6CC03114E
Article type
Communication
Submitted
14 Apr 2016
Accepted
11 May 2016
First published
11 May 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 7653-7656

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Screening of a virtual mirror-image library of natural products

T. Noguchi, S. Oishi, K. Honda, Y. Kondoh, T. Saito, H. Ohno, H. Osada and N. Fujii, Chem. Commun., 2016, 52, 7653 DOI: 10.1039/C6CC03114E

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