Issue 54, 2016
From the journal:

Chemical Communications

A DNAzyme-mediated logic gate for programming molecular capture and release on DNA origami†

Feiran Li,a   Haorong Chen,a   Jing Pan,a   Tae-Gon Cha,a   Igor L. Medintzb  and  Jong Hyun Choi*a  

* Corresponding authors

a School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
E-mail: jchoi@purdue.edu

b Centre for Bio/Molecular Science and Engineering, Code 6900 U.S. Naval Research Laboratory, Washington DC 20375, USA
E-mail: igor.medintz@nrl.navy.mil

Abstract

Here we design a DNA origami-based site-specific molecular capture and release platform operated by a DNAzyme-mediated logic gate process. We show the programmability and versatility of this platform with small molecules, proteins, and nanoparticles, which may also be controlled by external light signals.

Graphical abstract: A DNAzyme-mediated logic gate for programming molecular capture and release on DNA origami

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Article information

DOI
https://doi.org/10.1039/C6CC02989B
Article type
Communication
Submitted
10 Apr 2016
Accepted
16 May 2016
First published
16 May 2016

Chem. Commun., 2016,52, 8369-8372

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A DNAzyme-mediated logic gate for programming molecular capture and release on DNA origami

F. Li, H. Chen, J. Pan, T. Cha, I. L. Medintz and J. H. Choi, Chem. Commun., 2016, 52, 8369 DOI: 10.1039/C6CC02989B

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