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Issue 34, 2016

Tandem Rh-catalysis: decarboxylative β-keto acid and alkyne cross-coupling

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Abstract

Herein, we describe a regioselective Rh-catalyzed decarboxylative cross-coupling of β-keto acids and alkynes to access branched γ,δ-unsaturated ketones. Rh-hydride catalysis enables the isomerization of an alkyne to generate a metal-allyl species that can undergo carbon–carbon bond formation. Ketones are generated under mild conditions, without the need for base or activated electrophiles.

Graphical abstract: Tandem Rh-catalysis: decarboxylative β-keto acid and alkyne cross-coupling

Supplementary files

Article information


Submitted
05 Feb 2016
Accepted
24 Mar 2016
First published
29 Mar 2016

Chem. Commun., 2016,52, 5836-5839
Article type
Communication

Tandem Rh-catalysis: decarboxylative β-keto acid and alkyne cross-coupling

F. A. Cruz, Z. Chen, S. I. Kurtoic and V. M. Dong, Chem. Commun., 2016, 52, 5836 DOI: 10.1039/C6CC02522F

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