Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 51, 2016
Previous Article Next Article

Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing

Author affiliations

Abstract

RNA editing from adenosine to inosine (A-to-I editing) is one of the mechanisms that regulate and diversify the transcriptome. Here, a triplex-forming peptide nucleic acid (PNA) modified with a 2-aminopyridine nucleobase was applied for the recognition of the A-to-I editing event in double-stranded RNAs. The triplex-forming PNA enabled sequence-specific detection of single nucleobase editing at sub-nanomolar concentration.

Graphical abstract: Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Mar 2016, accepted on 27 Apr 2016 and first published on 27 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC02164F
Citation: Chem. Commun., 2016,52, 7935-7938

  •   Request permissions

    Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing

    C. Annoni, T. Endoh, D. Hnedzko, E. Rozners and N. Sugimoto, Chem. Commun., 2016, 52, 7935
    DOI: 10.1039/C6CC02164F

Search articles by author

Spotlight

Advertisements