Issue 38, 2016
From the journal:

Chemical Communications

New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis†

Lei Zhang,a   Jun Yuan,a   Yufang Xu,*a   Y.-H. Percival Zhang*b  and  Xuhong Qian*a  

* Corresponding authors

a Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: yfxu@ecust.edu.cn
Fax: +86 21 64252603
Tel: +86 21 64251399

b Biological Systems Engineering Department, Virginia Tech, 304 Seitz Hall, Blacksburg, Virginia 24061, USA

Abstract

A new artificial fluoro-cofactor was developed for the replacement of natural cofactors NAD(P), exhibiting a high hydride transfer ability. More importantly, we established a new and fast screening method for the evaluation of the properties of artificial cofactors based on the fluorescence assay and visible color change.

Graphical abstract: New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis

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Article information

DOI
https://doi.org/10.1039/C6CC02002J
Article type
Communication
Submitted
07 Mar 2016
Accepted
14 Apr 2016
First published
14 Apr 2016

Chem. Commun., 2016,52, 6471-6474

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New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis

L. Zhang, J. Yuan, Y. Xu, Y.-H. P. Zhang and X. Qian, Chem. Commun., 2016, 52, 6471 DOI: 10.1039/C6CC02002J

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