A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed.
K. V. Bukhryakov, V. G. Desyatkin and V. O. Rodionov, Chem. Commun., 2016, 52, 7576 DOI: 10.1039/C6CC01984F
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