Issue 41, 2016
From the journal:

Chemical Communications

Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides†

Hongxu Liu,b   Yanyan Yang,b   Jie Wu,b   Xiao-Na Wang*a  and  Junbiao Chang*ab  

* Corresponding authors

a Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China
E-mail: wangxn@zzu.edu.cn, changjunbiao@zzu.edu.cn

b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China

Abstract

A Pd(0)-catalyzed annulation reaction of ynamides is described for the efficient synthesis of 3,4-disubstituted isocoumarins. This novel methodology allows for the concomitant construction of O–C and C–C bonds between 2-iodoaromatic acids and ynamides, exhibiting excellent regioselectivities and a wide functional group tolerance.

Graphical abstract: Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides

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Article information

DOI
https://doi.org/10.1039/C6CC01565D
Article type
Communication
Submitted
20 Feb 2016
Accepted
14 Apr 2016
First published
18 Apr 2016

Chem. Commun., 2016,52, 6801-6804

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Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides

H. Liu, Y. Yang, J. Wu, X. Wang and J. Chang, Chem. Commun., 2016, 52, 6801 DOI: 10.1039/C6CC01565D

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