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Issue 39, 2016
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Acid-mediated topological control in a functionalized foldamer

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Abstract

Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.

Graphical abstract: Acid-mediated topological control in a functionalized foldamer

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Article information


Submitted
18 Feb 2016
Accepted
18 Mar 2016
First published
21 Mar 2016

Chem. Commun., 2016,52, 6521-6524
Article type
Communication

Acid-mediated topological control in a functionalized foldamer

P. C. Knipe, S. Thompson and A. D. Hamilton, Chem. Commun., 2016, 52, 6521
DOI: 10.1039/C6CC01496H

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