Jump to main content
Jump to site search

Issue 57, 2016
Previous Article Next Article

Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

Author affiliations

Abstract

Design and synthesis of pharmaceutical cocrystals have received great interest in recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and pharmacological properties such as solubility, stability, hydroscopicity, dissolution rates and bioavailability. It is now possible to engineer and develop cocrystals via ‘green chemistry’ and environmentally friendly approaches such as solid-state synthesis in the absence of organic solvents. In addition, significant efforts have been directed towards computational screening, cocrystal manufacturing in a continuous manner and real-time monitoring for quality purposes by using various analytical tools. Pharmaceutical cocrystals are not fully exploited yet and there is a lot of ground to cover before they can be successfully utilized as medical products.

Graphical abstract: Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

Back to tab navigation

Article information


Submitted
10 Feb 2016
Accepted
27 May 2016
First published
27 May 2016

Chem. Commun., 2016,52, 8772-8786
Article type
Feature Article
Author version available

Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

S. A. Ross, D. A. Lamprou and D. Douroumis, Chem. Commun., 2016, 52, 8772 DOI: 10.1039/C6CC01289B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements