Jump to main content
Jump to site search

Issue 36, 2016
Previous Article Next Article

In situ activation of a doxorubicin prodrug using imaging-capable nanoparticles

Author affiliations

Abstract

A general strategy for image-guided prodrug activation using fluorescently-labeled magnetic iron oxide nanoparticles is described. It is based on a recently developed concept in bio-orthogonal inverse-electron demand Diels–Alder chemistry, which is termed ‘click-to-release’. To illustrate a potential new biomedical application of the chemistry, the nanoparticles were modified with tetrazine, as well as near infrared fluorescent (NIRF) cy5.5 dye, while doxorubicin was converted into a prodrug. The nanoparticles taken up by the MDA-MB-231 breast cancer cells efficiently converted the prodrug of doxorubicin into the biologically active chemotherapeutic doxorubicin form.

Graphical abstract: In situ activation of a doxorubicin prodrug using imaging-capable nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Feb 2016, accepted on 01 Apr 2016 and first published on 01 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC01024E
Citation: Chem. Commun., 2016,52, 6174-6177
  •   Request permissions

    In situ activation of a doxorubicin prodrug using imaging-capable nanoparticles

    I. Khan, P. F. Agris, M. V. Yigit and M. Royzen, Chem. Commun., 2016, 52, 6174
    DOI: 10.1039/C6CC01024E

Search articles by author

Spotlight

Advertisements