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Issue 22, 2016
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Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

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Abstract

Two isomorphous cocrystals of nitazoxanide (NTZ) with p-aminosalicylic acid (PASA) and p-aminobenzoic acid (PABA) as well as their alloys were prepared by slurry and grinding techniques. The cocrystals exhibit faster dissolution rates and higher pharmacokinetic properties compared to the reference drug, and surprisingly the cocrystal alloy NTZ-PABA : NTZ-PASA (0.75 : 0.25) exhibited 4 fold higher bioavailability of NTZ in Sprague Dawley rats. This study opens the opportunity for cocrystal alloys as improved medicines.

Graphical abstract: Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

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Supplementary files

Article information


Submitted
31 Jan 2016
Accepted
15 Feb 2016
First published
18 Feb 2016

Chem. Commun., 2016,52, 4223-4226
Article type
Communication

Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

K. Suresh, M. K. C. Mannava and A. Nangia, Chem. Commun., 2016, 52, 4223
DOI: 10.1039/C6CC00975A

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