Issue 58, 2016

Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

Abstract

The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.

Graphical abstract: Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

Supplementary files

Article information

Article type
Communication
Submitted
16 Jan 2016
Accepted
17 Mar 2016
First published
29 Mar 2016

Chem. Commun., 2016,52, 9121-9124

Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

M. Müllner, D. Mehta, C. J. Nowell and C. J. H. Porter, Chem. Commun., 2016, 52, 9121 DOI: 10.1039/C6CC00447D

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