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Issue 58, 2016
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Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis

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Abstract

A fluorescent sensor – InR – with disaggregation-induced emission (DIE) characteristics has been developed for the label free detection of RecA inteins from Mycobacterium tuberculosis. Mechanistic studies demonstrate that InR binds at a hydrophobic pocket of RecA inteins, which is constituted by Gly435, Glu434, Arg405 and Arg 7, resulting in the disaggregation and recovery of its fluorescence.

Graphical abstract: Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis

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Publication details

The article was received on 16 Jan 2016, accepted on 19 Feb 2016 and first published on 19 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC00439C
Chem. Commun., 2016,52, 9086-9088

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    Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis

    X. Li, H. Jiang, Z. Luo, Y. Chang and L. Zhang, Chem. Commun., 2016, 52, 9086
    DOI: 10.1039/C6CC00439C

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