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Issue 22, 2016
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Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

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Abstract

The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate any chemical modification of the proteins, we present a novel and powerful strategy for the selective conjugation of recombinant protein domains with synthetically derived peptides via a cucurbit[8]uril host–guest chemistry approach.

Graphical abstract: Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

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Supplementary files

Article information


Submitted
15 Jan 2016
Accepted
19 Feb 2016
First published
22 Feb 2016

This article is Open Access

Chem. Commun., 2016,52, 4235-4238
Article type
Communication

Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

R. J. Gubeli, S. Sonzini, A. Podmore, P. Ravn, O. A. Scherman and C. F. van der Walle, Chem. Commun., 2016, 52, 4235
DOI: 10.1039/C6CC00405A

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