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Issue 32, 2016
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The HA-incorporated nanostructure of a peptide–drug amphiphile for targeted anticancer drug delivery

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Abstract

A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK–CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK–CPT exhibited target specific toxicity with excellent antitumour efficiency.

Graphical abstract: The HA-incorporated nanostructure of a peptide–drug amphiphile for targeted anticancer drug delivery

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Article information


Submitted
08 Jan 2016
Accepted
22 Mar 2016
First published
22 Mar 2016

Chem. Commun., 2016,52, 5637-5640
Article type
Communication

The HA-incorporated nanostructure of a peptide–drug amphiphile for targeted anticancer drug delivery

H. Choi, M. T. Jeena, L. Palanikumar, Y. Jeong, S. Park, E. Lee and J. Ryu, Chem. Commun., 2016, 52, 5637
DOI: 10.1039/C6CC00200E

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