Issue 23, 2016

Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes

Abstract

A palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes has been developed. This study unveils that a critical substrate dependent acid concentration is essential for achieving exclusive C-2 selectivity as well as mono-arylation in pyrroles. Incongruent to the literature, the protocol uses a reduced volume (at least 5 times) of arenes for workable access to C-2 arylated heterocycles.

Graphical abstract: Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes

Supplementary files

Article information

Article type
Communication
Submitted
06 Jan 2016
Accepted
17 Feb 2016
First published
19 Feb 2016

Chem. Commun., 2016,52, 4329-4332

Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes

J. K. Laha, R. A. Bhimpuria, D. V. Prajapati, N. Dayal and S. Sharma, Chem. Commun., 2016, 52, 4329 DOI: 10.1039/C6CC00133E

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