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Issue 58, 2016
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Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes

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Abstract

A transition-metal-free three-component coupling involving N-substituted aziridines, arynes and aldehydes resulting in the formation of trisubstituted N-aryl α-amino epoxides has been demonstrated. The reaction likely proceeds via the highly strained cyclic nitrogen ylide intermediates generated from aziridines and arynes.

Graphical abstract: Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes

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Publication details

The article was received on 04 Jan 2016, accepted on 19 Jan 2016 and first published on 20 Jan 2016


Article type: Communication
DOI: 10.1039/C6CC00057F
Citation: Chem. Commun., 2016,52, 9044-9047
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    Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes

    T. Roy, M. Thangaraj, R. G. Gonnade and A. T. Biju, Chem. Commun., 2016, 52, 9044
    DOI: 10.1039/C6CC00057F

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