Issue 58, 2016

Chemical fragment arrays for rapid druggability assessment

Abstract

Incorporation of early druggability assessment in the drug discovery process provides a means to prioritize target proteins for high-throughput screening. We present chemical fragment arrays as a method that is capable of determining the druggability of a given target with low protein and compound consumption, enabling rapid decision making during early phases of drug discovery.

Graphical abstract: Chemical fragment arrays for rapid druggability assessment

Supplementary files

Article information

Article type
Communication
Submitted
21 Dec 2015
Accepted
10 Feb 2016
First published
10 Feb 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 9067-9070

Author version available

Chemical fragment arrays for rapid druggability assessment

J. Aretz, Y. Kondoh, K. Honda, U. R. Anumala, M. Nazaré, N. Watanabe, H. Osada and C. Rademacher, Chem. Commun., 2016, 52, 9067 DOI: 10.1039/C5CC10457B

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