Issue 24, 2016
From the journal:

Chemical Communications

Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation†

Hiroyasu Tabe,a   Takuya Shimoi,b   Marion Boudes,c   Satoshi Abe,b   Fasséli Coulibaly,c   Susumu Kitagawa,*a   Hajime Morid  and  Takafumi Ueno*b  

* Corresponding authors

a Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: kitagawa@icems.kyoto-u.ac.jp

b Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 224-8501, Japan
E-mail: tueno@bio.titech.ac.jp

c Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC3800, Australia

d Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

Abstract

Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.

Graphical abstract: Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

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Article information

DOI
https://doi.org/10.1039/C5CC10440H
Article type
Communication
Submitted
20 Dec 2015
Accepted
29 Feb 2016
First published
01 Mar 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 4545-4548

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Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

H. Tabe, T. Shimoi, M. Boudes, S. Abe, F. Coulibaly, S. Kitagawa, H. Mori and T. Ueno, Chem. Commun., 2016, 52, 4545 DOI: 10.1039/C5CC10440H

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