Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by 129Xe hyperCEST NMR

Joel A. Finbloom; Clancy C. Slack; Carson J. Bruns; Keunhong Jeong; David E. Wemmer; Alexander Pines; Matthew B. Francis

doi:10.1039/C5CC10410F

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Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by ¹²⁹Xe hyperCEST NMR†

Joel A. Finbloom,^a Clancy C. Slack,^ab Carson J. Bruns,^a Keunhong Jeong,^ab David E. Wemmer,^ac Alexander Pines^ab and Matthew B. Francis*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA

^b Materials Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, CA, USA

^c Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720
E-mail: mbfrancis@berkeley.edu

Abstract

We report a method for blocking interactions between ¹²⁹Xe and cucurbit[6]uril (CB6) until activation by a specific chemical event. We synthesized a CB6–rotaxane that allowed no ¹²⁹Xe interaction with the CB6 macrocycle component until a cleavage event released the CB6, which then produced a ¹²⁹Xe@CB6 NMR signal. This contrast-upon-activation ¹²⁹Xe NMR platform allows for modular synthesis and can be expanded to applications in detection and disease imaging.

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Article information

DOI: https://doi.org/10.1039/C5CC10410F
Article type: Communication
Submitted: 18 Dec 2015
Accepted: 13 Jan 2016
First published: 15 Jan 2016

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Chem. Commun., 2016,52, 3119-3122

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Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by ¹²⁹Xe hyperCEST NMR

J. A. Finbloom, C. C. Slack, C. J. Bruns, K. Jeong, D. E. Wemmer, A. Pines and M. B. Francis, Chem. Commun., 2016, 52, 3119 DOI: 10.1039/C5CC10410F

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