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Issue 27, 2016
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Imidazolium-tagged glycan probes for non-covalent labeling of live cells

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Abstract

Selective, bioorthogonal and fast labeling of glycoconjugates in living cells is a major challenge for synthetic and cellular biology. Here we report the use imidazolium tagged-mannosamine derivative (ITag-Man) for the non-covalent, rapid and site-specific labeling of sialic acid containing glycoproteins using commercial N-nitrilotriacetate fluorescent reagents in a range of cell lines.

Graphical abstract: Imidazolium-tagged glycan probes for non-covalent labeling of live cells

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Supplementary files

Article information


Submitted
06 Dec 2015
Accepted
07 Mar 2016
First published
07 Mar 2016

This article is Open Access

Chem. Commun., 2016,52, 4906-4909
Article type
Communication
Author version available

Imidazolium-tagged glycan probes for non-covalent labeling of live cells

D. Benito-Alifonso, S. Tremell, J. C. Sadler, M. Berry and M. C. Galan, Chem. Commun., 2016, 52, 4906
DOI: 10.1039/C5CC10040B

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