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Issue 23, 2016
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Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(III) complex as correlative label

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Abstract

We present the synthesis of polylactide by ring-opening polymerization using a luminescent iridium(III) complex acting as initiator. The polymer was formulated into nanoparticles, which were taken up by HEK-293 cells. We could show that the particles provided an appropriate contrast in both superresolution fluorescence and electron microscopy, and, moreover, are non-toxic, in contrast to the free iridium complex.

Graphical abstract: Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(iii) complex as correlative label

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Publication details

The article was received on 30 Nov 2015, accepted on 22 Feb 2016 and first published on 22 Feb 2016


Article type: Communication
DOI: 10.1039/C5CC09884J
Citation: Chem. Commun., 2016,52, 4361-4364
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    Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(III) complex as correlative label

    M. Reifarth, D. Pretzel, S. Schubert, C. Weber, R. Heintzmann, S. Hoeppener and U. S. Schubert, Chem. Commun., 2016, 52, 4361
    DOI: 10.1039/C5CC09884J

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