A novel protocol to synthesize multisubstituted benzo[b][1,4]oxazepines from N-(2-haloaryl)enaminones has been developed. In this procedure, only 2 equiv. of Cs2CO3 was required. A variety of polysubstituted benzo[b][1,4]oxazepine derivatives were provided in up to 95% yield for 27 examples.
![Graphical abstract: The base-promoted synthesis of multisubstituted benzo[b][1,4]oxazepines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC09877G&imageInfo.ImageIdentifier.Year=2016)
J. Shen, L. Xue, X. Lin, G. Cheng and X. Cui, Chem. Commun., 2016, 52, 3292 DOI: 10.1039/C5CC09877G
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