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Issue 13, 2016
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3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability

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Abstract

Ambient light stable 3-trifluoromethyl-3-aryldiazirine photolabels are developed via stabilization of the strained three membered diazirine ring by replacing the phenyl ring with electron withdrawing heterocyclic rings. Photolabeling studies reveal that these ambient light stable photolabels are equally efficient in photolabeling target proteins as the traditional 3-trifluoromethyl-3-phenyldiazirine and found to significantly increase the aqueous solubility of the photoaffinity labels.

Graphical abstract: 3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability

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Supplementary files

Article information


Submitted
17 Nov 2015
Accepted
29 Dec 2015
First published
04 Jan 2016

Chem. Commun., 2016,52, 2729-2732
Article type
Communication
Author version available

3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability

A. B. Kumar, J. D. Tipton and R. Manetsch, Chem. Commun., 2016, 52, 2729
DOI: 10.1039/C5CC09518B

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