Jump to main content
Jump to site search

Issue 13, 2016
Previous Article Next Article

3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability

Author affiliations

Abstract

Ambient light stable 3-trifluoromethyl-3-aryldiazirine photolabels are developed via stabilization of the strained three membered diazirine ring by replacing the phenyl ring with electron withdrawing heterocyclic rings. Photolabeling studies reveal that these ambient light stable photolabels are equally efficient in photolabeling target proteins as the traditional 3-trifluoromethyl-3-phenyldiazirine and found to significantly increase the aqueous solubility of the photoaffinity labels.

Graphical abstract: 3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Nov 2015, accepted on 29 Dec 2015 and first published on 04 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC09518B
Author version
available:
Download author version (PDF)
Citation: Chem. Commun., 2016,52, 2729-2732
  •   Request permissions

    3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability

    A. B. Kumar, J. D. Tipton and R. Manetsch, Chem. Commun., 2016, 52, 2729
    DOI: 10.1039/C5CC09518B

Search articles by author

Spotlight

Advertisements