Issue 6, 2016
From the journal:

Chemical Communications

Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery†

Yong Wang,‡a   Hong Xiao,‡a   Jing Fang,b   Xingsu Yu,b   Zhenwei Su,a   Du Chenga  and  Xintao Shuai*ab  

* Corresponding authors

a PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
E-mail: shuaixt@mail.sysu.edu.cn
Fax: +86-20-84112245
Tel: +86-20-84110365

b Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

Abstract

A novel siRNA delivery system based on a triblock copolymer with pH and reduction dual-sensitivity was introduced. The polyplex, having high delivery efficiency not dependent on surface charge reversion in response to the pH value of tumor tissue, was used for target gene silencing in cancer therapy.

Graphical abstract: Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery

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Article information

DOI
https://doi.org/10.1039/C5CC09181K
Article type
Communication
Submitted
05 Nov 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Chem. Commun., 2016,52, 1194-1197

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Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery

Y. Wang, H. Xiao, J. Fang, X. Yu, Z. Su, D. Cheng and X. Shuai, Chem. Commun., 2016, 52, 1194 DOI: 10.1039/C5CC09181K

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