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Issue 10, 2016
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Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

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Abstract

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

Graphical abstract: Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

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Supplementary files

Article information


Submitted
05 Nov 2015
Accepted
14 Dec 2015
First published
15 Dec 2015

Chem. Commun., 2016,52, 2126-2128
Article type
Communication
Author version available

Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

K. B. Daniel, C. E. Callmann, N. C. Gianneschi and S. M. Cohen, Chem. Commun., 2016, 52, 2126
DOI: 10.1039/C5CC09164K

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