Jump to main content
Jump to site search

Issue 11, 2016
Previous Article Next Article

Highly enantioselective hydrogenation of α-oxy functionalized α,β-unsaturated acids catalyzed by a ChenPhos–Rh complex in CF3CH2OH

Author affiliations

Abstract

Rhodium complexes coordinated by Chenphos are very effective catalysts for the enantioselective hydrogenation of α-aryloxy- and α-alkoxy-substituted α,β-unsaturated carboxylic acids under mild conditions in CF3CH2OH. The catalytic system could be successfully employed in building the core structure of a new FDA approved drug LCZ 696.

Graphical abstract: Highly enantioselective hydrogenation of α-oxy functionalized α,β-unsaturated acids catalyzed by a ChenPhos–Rh complex in CF3CH2OH

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Nov 2015, accepted on 25 Nov 2015 and first published on 26 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC09089J
Author version
available:
Download author version (PDF)
Citation: Chem. Commun., 2016,52, 2273-2276
  •   Request permissions

    Highly enantioselective hydrogenation of α-oxy functionalized α,β-unsaturated acids catalyzed by a ChenPhos–Rh complex in CF3CH2OH

    L. Yao, J. Wen, S. Liu, R. Tan, N. M. Wood, W. Chen, S. Zhang and X. Zhang, Chem. Commun., 2016, 52, 2273
    DOI: 10.1039/C5CC09089J

Search articles by author

Spotlight

Advertisements