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Issue 7, 2016
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A mild hydration of nitriles catalysed by copper(ii) acetate

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Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Graphical abstract: A mild hydration of nitriles catalysed by copper(ii) acetate

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Article information


Submitted
20 Oct 2015
Accepted
20 Nov 2015
First published
20 Nov 2015

Chem. Commun., 2016,52, 1436-1438
Article type
Communication
Author version available

A mild hydration of nitriles catalysed by copper(II) acetate

P. Marcé, J. Lynch, A. J. Blacker and J. M. J. Williams, Chem. Commun., 2016, 52, 1436
DOI: 10.1039/C5CC08714G

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