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Issue 6, 2016
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Platinum nanoparticles encapsulated metal–organic frameworks for the electrochemical detection of telomerase activity

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Abstract

A simple and rapid electrochemical sensor is constructed for the detection of telomerase activity based on the electrocatalysis of platinum nanoparticle (Pt NP) encapsulated metal–organic frameworks (MOFs), which are synthesized by one-pot encapsulation of Pt NPs into prototypal MOFs, UiO-66-NH2. Integrating with the efficient electrocatalysis of Pt@MOFs towards NaBH4 oxidation, this biosensor shows the wide dynamic correlation of telomerase activity from 5 × 102 to 107 HeLa cells mL−1 and the telomerase activity in a single HeLa cell was calculated to be 2.0 × 10−11 IU, providing a powerful platform for detecting telomerase activity.

Graphical abstract: Platinum nanoparticles encapsulated metal–organic frameworks for the electrochemical detection of telomerase activity

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Publication details

The article was received on 10 Oct 2015, accepted on 17 Nov 2015 and first published on 17 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08418K
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Chem. Commun., 2016,52, 1226-1229

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    Platinum nanoparticles encapsulated metal–organic frameworks for the electrochemical detection of telomerase activity

    P. Ling, J. Lei, L. Jia and H. Ju, Chem. Commun., 2016, 52, 1226
    DOI: 10.1039/C5CC08418K

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