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Issue 4, 2016
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Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

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Abstract

We report the labelling of dideoxy nucleotides (ddNTPs) for use in electrochemical array based primer extension for the detection of single nucleotide polymorphisms (SNPs). The results confirm the extension of the immobilised primers for each of the four ddNTPs, representing a significant advance in achieving a cost-effective platform for screening of disease-specific SNPs.

Graphical abstract: Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

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Publication details

The article was received on 16 Sep 2015, accepted on 27 Oct 2015 and first published on 04 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC07762A
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Citation: Chem. Commun., 2016,52, 757-759
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    Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

    A. M. Debela, S. Thorimbert, B. Hasenknopf, C. K. O'Sullivan and M. Ortiz, Chem. Commun., 2016, 52, 757
    DOI: 10.1039/C5CC07762A

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