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Issue 1, 2016
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Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

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Abstract

Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

Graphical abstract: Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

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Supplementary files

Article information


Submitted
05 Aug 2015
Accepted
21 Oct 2015
First published
21 Oct 2015

Chem. Commun., 2016,52, 160-163
Article type
Communication
Author version available

Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

L. F. Vistain, M. W. Rotz, R. Rathore, A. T. Preslar and T. J. Meade, Chem. Commun., 2016, 52, 160
DOI: 10.1039/C5CC06565H

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