Jump to main content
Jump to site search

Issue 9, 2016
Previous Article Next Article

Recent progress in nanomaterials for gene delivery applications

Author affiliations

Abstract

Nanotechnology-based gene delivery is the division of nanomedicine concerned with the synthesis, characterization, and functionalization of nanomaterials to be used in targeted-gene delivery applications. Nanomaterial-based gene delivery systems hold great promise for curing fatal inherited and acquired diseases, including neurological disorders, cancer, cardiovascular diseases, and acquired immunodeficiency syndrome (AIDS). However, their use in clinical applications is still controversial. To date, the Food and Drug Administration (FDA) has not approved any gene delivery system because of the unknown long-term toxicity and the low gene transfection efficiency of nanomaterials in vivo. Compared to viral vectors, nonviral gene delivery vectors are characterized by a low preexisting immunogenicity, which is important for preventing a severe immune response. In addition, nonviral vectors provide higher loading capacity and ease of fabrication. For these reasons, this review article focuses on applications of nonviral gene delivery systems, including those based on lipids, polymers, graphene, and other inorganic nanoparticles, and discusses recent advances in nanomaterials for gene therapy. Methods of synthesizing these nanomaterials are briefly described from a materials science perspective. Also, challenges, critical issues, and concerns about the in vivo applications of nanomaterial-based gene delivery systems are discussed. It should be noted that this article is not a comprehensive review of the literature.

Graphical abstract: Recent progress in nanomaterials for gene delivery applications

Back to tab navigation

Publication details

The article was received on 01 Jul 2016, accepted on 15 Jul 2016 and first published on 02 Aug 2016


Article type: Review Article
DOI: 10.1039/C6BM00441E
Author version
available:
Download author version (PDF)
Citation: Biomater. Sci., 2016,4, 1291-1309
  •   Request permissions

    Recent progress in nanomaterials for gene delivery applications

    E. Keles, Y. Song, D. Du, W. Dong and Y. Lin, Biomater. Sci., 2016, 4, 1291
    DOI: 10.1039/C6BM00441E

Search articles by author

Spotlight

Advertisements