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Issue 4, 2016
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Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

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Abstract

Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.

Graphical abstract: Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

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Publication details

The article was received on 08 Nov 2015, accepted on 14 Dec 2015 and first published on 21 Dec 2015


Article type: Communication
DOI: 10.1039/C5BM00514K
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Citation: Biomater. Sci., 2016,4, 610-613
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    Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

    F. M. Kievit, K. Wang, A. E. Erickson, S. K. Lan Levengood, R. G. Ellenbogen and M. Zhang, Biomater. Sci., 2016, 4, 610
    DOI: 10.1039/C5BM00514K

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