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Issue 20, 2016
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Online monitoring of ethanol concentration using a responsive microfluidic membrane device

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Abstract

A novel method for online monitoring of ethanol concentration has been proposed by successfully developing an ethanol-responsive microfluidic membrane device. The microfluidic membrane device is fabricated by bonding two patterned polydimethylsiloxane (PDMS) modules with a sandwiched ethanol-responsive membrane via a “stamp-like” method. The PDMS modules are prepared by soft lithography and the ethanol-responsive membrane is prepared by blending poly(N-isopropylacrylamide) nanogels into the membrane-forming solution via a vapor-induced phase separation process. The developed microfluidic membrane device shows excellent ethanol-responsive characteristics, rapid responsive rate, and good repeatability and stability. With the microfluidic membrane device, a significant difference in fluxes of ethanol solutions with different concentrations can be directly observed. At certain temperatures, the microfluidic membrane device shows critical responsive ethanol concentrations around 10 vol%, e.g., 13.0 vol% at 25 °C and 7.8 vol% at 30 °C. For real fermentation broths, the microfluidic membrane device still shows excellent response and detection performances, which demonstrates that the microfluidic membrane device is highly promising to be applied to monitor the ethanol concentration in fermentation processes.

Graphical abstract: Online monitoring of ethanol concentration using a responsive microfluidic membrane device

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Publication details

The article was received on 12 Feb 2016, accepted on 14 Apr 2016 and first published on 14 Apr 2016


Article type: Paper
DOI: 10.1039/C6AY00432F
Anal. Methods, 2016,8, 4028-4036

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    Online monitoring of ethanol concentration using a responsive microfluidic membrane device

    X. Zou, F. Luo, R. Xie, L. Zhang, X. Ju, W. Wang, Z. Liu and L. Chu, Anal. Methods, 2016, 8, 4028
    DOI: 10.1039/C6AY00432F

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