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Issue 9, 2016
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The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs

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Abstract

A dynamic coating using polyamidoamine (PAMAM) dendrimers was used to change the direction and magnitude of electroosmotic flow. The influence of PAMAM on electroosmotic mobility was studied in the concentration range from 0.005 to 0.100% (w/v) and at different electrolyte pH values from 2.5 to 8.5. PAMAM dendrimers, as an additive to the background electrolyte, were able to reverse the electroosmotic flow at a low concentration level (0.01% w/v). The presented dynamic coating was then applied to the enantioseparation of selected amines such as R,S- and S,R-tapentadol, R- and S-isoproterenol and R,S- and S,R-ephedrine with the use of 2-hydroxypropyl-β-cyclodextrin as the chiral selector.

Graphical abstract: The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs

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Article information


Submitted
24 Nov 2015
Accepted
09 Feb 2016
First published
11 Feb 2016

Anal. Methods, 2016,8, 1968-1972
Article type
Communication
Author version available

The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs

J. Znaleziona and V. Maier, Anal. Methods, 2016, 8, 1968
DOI: 10.1039/C5AY03070F

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