We report a simple method for fluorescence detection of single-nucleotide alterations in a long target DNA, which is based on the formation of a three-way-junction-structured cholic-acid-binding DNA aptamer by the hybridization of the target with binary DNA probes. The new method was successfully exploited for SNP genotyping of human CYP2C19 gene.
S. Kamoto, M. Hyuga and T. Kato, Analyst, 2016, 141, 6087 DOI: 10.1039/C6AN00912C
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