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Issue 12, 2016
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A fully battery-powered inexpensive spectrophotometric system for high-sensitivity point-of-care analysis on a microfluidic chip

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Abstract

A cost-effective [b with combining low line][a with combining low line]ttery-powered [s with combining low line]pectrophotometric [s with combining low line]ystem (BASS) was developed for quantitative point-of-care (POC) analysis on a microfluidic chip. By using methylene blue as a model analyte, we first compared the performance of the BASS with a commercial spectrophotometric system, and further applied the BASS for loop-mediated isothermal amplification (LAMP) detection and subsequent quantitative nucleic acid analysis which exhibited a comparable limit of detection to that of Nanodrop. Compared to the commercial spectrophotometric system, our spectrophotometric system is lower-cost, consumes less reagents, and has higher detection sensitivity. Most importantly, it does not rely on external power supplies. All these features make our spectrophotometric system highly suitable for a variety of POC analyses, such as field detection.

Graphical abstract: A fully battery-powered inexpensive spectrophotometric system for high-sensitivity point-of-care analysis on a microfluidic chip

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Article information


Submitted
14 Feb 2016
Accepted
20 Apr 2016
First published
20 Apr 2016

Analyst, 2016,141, 3898-3903
Article type
Paper
Author version available

A fully battery-powered inexpensive spectrophotometric system for high-sensitivity point-of-care analysis on a microfluidic chip

M. Dou, J. Lopez, M. Rios, O. Garcia, C. Xiao, M. Eastman and X. Li, Analyst, 2016, 141, 3898
DOI: 10.1039/C6AN00370B

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